Welcome to the registration page of the
4th MOSBRI scientific conference
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4th MOSBRI scientific conference
June 10-13, 2025
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Tuesday, June 10, 2025
Welcome coffee |
1.00 pm-2.00 pm
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Opening/Welcome (Patrick ENGLAND) |
2.00 pm-2.15 pm
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Macromolecular assemblies : architecture, energetics and dynamics |
2.15 pm-6.30 pm
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Chairs: Francesca Cutruzzola, Sapienza University of Rome, Italy - Valérie Belle, Aix-Marseille Université, France |
1
2.15 pm |
Biophysical insights into SHMT non-canonical roles: from RNA interactions to the de novo thymidylate synthesis complex
Sharon Spizzichino Dept. of Biochemical Sciences, Sapienza University of Rome, Rome, Italy
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2
2.40 pm |
Understanding clathrin assembly through cryo-electron microscopy structures of clathrin cages assembled in the absence of adaptor proteins
Corinne Smith School of Life Sciences, University of Warwick, Coventry, United Kingdom
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3
2.55 pm |
Characterization of Rabies virus phosphoprotein thermoresponsive liquid-liquid phase separation
Caroline Mas Université Grenoble Alpes, CNRS, CEA, EMBL, ISBG, 38000, Grenoble, France, Grenoble, France
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4
3.10 pm |
VDAC2-mediated Bax membrane insertion: A structural and functional study
Varun Ravishankar Laboratoire d'Ingénierie des Systèmes Macromoléculaires (LISM), Aix-Marseille University, CNRS, Marseille, France Laboratoire de Bioénergétique et Ingénierie des Protéines (BIP), Aix-Marseille University, CNRS, Marseille, France
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5
3.25 pm |
Unveiling the effect of phosphorylation on the structural and aggregation properties of DPF3a an amyloidogenic intrinsically disordered protein
Tanguy Leyder Chemistry, UCPTS, CPB lab, Université de Namur, Namur, Belgium
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6
3.40 pm |
Phase Separation in Biology, Aging & Disease
Thom Leiding CEO and Founder, Labbot, Sweden
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7
4.30 pm |
Ex-vivo structural biology: toxic protein species in systemic amyloidosis
Stefano Ricagno Université de Milan, Milan, Italy
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8
4.55 pm |
Insights into a colorimetric metalloprotein - Purple Acid Phosphatase and the origin of color in Iron containing proteins
Aishwarya Venkatramani University of Cambridge, Cambridge, United Kingdom
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9
5.10 pm |
Unveiling Hidden Insights: Enhanced Analytics with New Heights of Sensitivity
Christophe Quétard PhD, Field Application Specialist BioAnalytics, Sartorius, Dourdan, France
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10
5.20 pm |
Revealing surfaces and solvent interactions of macromolecular assemblies by solid-state NMR analysis
Patrick Van Der Wel Zernike Institute for Advanced Materials, University of Groningen, Groningen, The Netherlands
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11
5.35 pm |
A PDZ tandem repeat folds and unfolds via different pathways
Valeria Pennacchietti Università La Sapienza, Roma, Italy
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12
5.50 pm |
Taylor Dispersion Analysis for Amyloid-Beta Peptides Aggregation: A Novel Tool in Alzheimer’s Research
Joseph Chamieh IBMM - University of Montpellier, Montpellier, France
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13
6.05 pm |
Enzymes from Neisseria gonorrhoeae and Escherichia coli important during infection
Sofia R. Pauleta Microbial Stress, Dept. Química, NOVA FCT, UCIBIO-NOVA, Caparica, Portugal
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14
6.20 pm |
Insights into ultracentrifugation and flow cytometry for the separation and characterization of small particles
Lutz Ehrhardt Market Development Manager Centrifugation, Global marketing at Beckman Coulter Life Sciences, Villepinte, France
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1st Poster session |
6.30 pm-8.30 pm
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Conference cocktail |
7.15 pm-10.00 pm
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Wednesday, June 11, 2025
Welcome coffee |
08.30 am-09.00 am
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Macromolecular engineering and structure/function studies |
09.00 am-1.05 pm
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Chair: Gregor Anderluh, National Institute of Chemistry, Slovenia |
15
09.00 am |
Designed macromolecular assemblies for in situ delivery of therapeutic proteins
Andreas Plückthun Dept. Biochemistry, Universität Zürich, Zurich, Switzerland
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16
09.40 am |
Scaffold-derived peptides as protein-protein interaction (PPI) inhibitors to target the AuroraA/N-Myc complex in MYCN-amplified neuroblastoma
Simone Rossi Institut des Sciences Analytiques - UMR5280, Université Claude Bernard Lyon 1, Villeurbanne, France
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17
09.55 am |
Lego-like peptide assembly of honeycomb multichannel nanofibrils
Francesca Mazzotta Physical Chemistry of Polymers, Max Planck Insitute for Polymer Research, Mainz, Germany
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18
10.10 am |
Innovative self-assembling peptide biomaterial for targeted prostate cancer drug delivery
Bárbara Matos INEB - Instituto de Engenharia Biomédica, Universidade do Porto, Porto, Portugal, Porto, Portugal i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal, Porto, Portugal
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19
10.25 am |
De novo design of transmembrane beta-barrel nanopores with defined shapes and functions
Anastassia Vorobieva Vrije Universiteit Brussel, Bruxelles, Belgium
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20
11.20 am |
Remarkable structural plasticity and tunability of the potyviral coat protein
Marjetka Podobnik Department of Molecular Biology and Nanobiotechnology, National Institute of Chemistry, Ljubljana, Slovenia
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21
11.45 am |
Identifying allosteric inhibitors of human histone deacetylase 8 (HDAC8)
Adrian Velazquez-Campoy Institute BIFI - LACRIMA, University of Zaragoza, Zaragoza, Spain Department of Biochemistry and Molecular and Cell Biology, University of Zaragoza, Zaragoza, Spain
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22
12.00 pm |
Leveraging the E222Q replacement to generate novel reversibly switchable fluorescent Aequorea victoria proteins for super-resolution imaging
Ranieri Bizzarri NEST, Istituto Nanoscienze (CNR-NANO) and Scuola Normale Superiore, Consiglio Nazionale delle Ricerche, Pisa, Italy Department of Surgical, medical, Molecular Pathology and Critical Care medicine, University of Pisa, Pisa, Italy
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23
12.15 pm |
Designing, developing, and evaluating a protein-peptide binding system for fundamental biophysics and biophysical instrument evaluation
Mark Williams BiophysX Centre, Birkbeck, University of London, London, United Kingdom
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24
12.30 pm |
Understanding Carbonic Anhydrase Inhibition: Structural and Thermodynamic Insights
Vaida Paketuryte-Latve departmant of biothermodynamics and drugs design, Vilnius University, Vilnius, Lithuania
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25
12.45 pm |
Pushing The Boundaries in Biomolecular Interaction Analysis with the Creoptix WAVE system
Aymeric Audfray PhD, Field Application Scientist, Malvern Panalytical, France
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26
12.55 pm |
Advancing Molecular Interaction Analysis with FIDA Technology
Marion Albasini Fida Biosystems ApS, Soborg, Denmark
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Artificial intelligence, computational approaches and data analysis |
2.15 pm-6.15 pm
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Chair: Javier Sancho, University of Zaragoza, Spain |
27
2.15 pm |
De novo design of new-to-nature immunoglobulin-like proteins using deep learning
Enrique Marcos Benteo Institute of Molecular Biology of Barcelona, Barcelone, Spain
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28
2.40 pm |
Charting γ-secretase substrates by explainable AI
Dmitrij Frishman Technical University of Munich, Freising, Germany
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29
2.55 pm |
Protein-Ligan Binding Database (PLBD) of Affinities and Enthalpies for AI-ML in Drug Discovery
Daumantas Matulis Biothermodynamics and Drug Design, Vilnius University, Vilnius, Lithuania
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30
3.10 pm |
AFMfit : Deciphering conformational dynamics in AFM data using fast nonlinear NMA and FFT-based search
Rémi Vuillemot Laboratoire Jean Kuntzmann - CNRS, France
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31
3.25 pm |
Seeing Structure, Seeking Function: Enabling Molecular Insight with Rigaku
Kanda Hiroyuki Senior Director & Global Product Leader, Life Science Product Division, Rigaku Corporation, Tokyo, Japan
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32
3.35 pm |
MAGNA™: A novel single molecule approach for the real-time analysis of biomolecular interactions using magnetic force spectroscopy
Elie Hammam Field Application Scientist, Depixus SAS, France
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33
4.15 pm |
The interplay of key parameters in the transport process of small synthetic chloride carriers
Sara Boi University of Cagliari, Monserrato, Italy
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34
4.30 pm |
Managing raw biophysical data under the Molecular Biophysics Database
Jan Dohnálek Laboratory of Structure and Function of Biomolecules, MoB-IBT, Institute of Biotechnology of the Czech Academy of Sciences, Vestec, Czech Republic
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35
4.55 pm |
KinGenie, an online, user-friendly tool to analyse surface- and solution-based binding kinetics
Osvaldo Burastero European Molecular Biology Laboratory, Hamburg, Germany
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36
5.10 pm |
Identification of aggregation prone regions in amyloidogenic proteins by combining multidimensional predictions and molecular dynamics
Julien Mignon Department of Chemistry, Laboratoire de Chimie Physique des Biomolécules, University of Namur, Namur, Belgium
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37
5.25 pm |
Meet Aunty, the Queen of high throughput protein stability
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38
5.35 pm |
Visualizing the unseen: conversation on a journey through Art and Science
Giorgio Giardina Sapienza University, Rome, Italy
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2nd Poster session |
6.15 pm-7.55 pm
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Thursday, June 12, 2025
Welcome coffee |
08.30 am-09.00 am
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Molecular biophysics In situ/in vivo and in biomimetic environments |
09.00 am-1.05 pm
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Chair: Lorena Redondo-Morata, Dynamics and nanoenvironment of biological membranes, France |
39
09.00 am |
A universal scaling law for mitotic spindles across eukaryotes driven by chromosome crowding
Iva Tolic RBI Zagreb, Zagreb, Croatia
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40
09.40 am |
Membrane damage by α-synuclein is preceded by an increase in lipid packing energy
Claudio Canale Dept. of Physics, University of Genoa, Genova, Italy
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41
09.55 am |
Functional reconstitution of Mfn2-Mediated Fusion in PE-Enriched Vesicles
Ivan Lopez Montero Universidad Complutense de Madrid, Madrid, Spain
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42
10.10 am |
Resolving individual multi-molecular interactions in living cells
Maria Garcia-Parajo Institute of Photonic Sciences, Barcelone, Spain
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43
10.35 am |
Dynamic Equilibrium of a Bacterial Chaperone: Cellular Factors Promote the Closed Conformation
Angeliki Giannouli Department of Chemistry, University of Crete, Heraklion, Greece BIP, Bioénergétique et Ingénierie des Protéines, Aix Marseille University, Marseille, France
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44
11.30 am |
Unraveling Lipid Membrane Dynamics and Phase Behavior Using AFM
Lorena Redondo-Morata Aix-Marseille University, INSERM, DyNaMo, Turing centre for living systems, Marseille, France
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45
11.55 am |
Focal Molography - A Label-Free Platform for Real-Time Analysis of Molecular Interactions in Living Cells
Andreas Frutiger lino Biotech AG, Adliswil, Switzerland
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46
12.10 pm |
MEASURING BACTERIAL OXYGEN CONSUMPTION RATE TO PROBE METABOLIC SIGNATURE AND ANTIMICROBIAL SUSCEPTIBILITY
Serena Rinaldo Biochemical Sciences, Sapienza University of Rome, Rome, Italy
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47
12.25 pm |
Assessment of the colloidal stability of carbon nano-onions-DNA hybrid materials for further nanomedicine applications
Julia Mónica Requena Ramirez Departamento de Química Inorgánica, Instituto De Ciencia Molecular (Universidad De Valencia), Valencia, Spain
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48
12.40 pm |
Plant vs Dairy protein stabilised cappuccino foams: how protein and hydrocolloid conformational changes affect foam stability.
Timothy Wooster Institute of Food Sciences, Nestlé Research, Lausanne, Switzerland
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49
12.55 pm |
Biophysical investigation of antibodies from high-throughput screening to in-depth characterization on cells
Stephane Pinhal Bruker Daltonics GmbH & Co. KG, Germany
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Molecular biophysics to address societal challenges (climate change, infectious or degenerative diseases, ...) |
2.15 pm-6.05 pm
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Chair: Adriana Erica Miele, Université Claude Bernard Lyon 1, France |
50
2.15 pm |
Atomic Force Microscopy: Unveiling Tuberculosis and Malaria Through Imaging and Force Spectroscopy
Thomas Gutsmann Biophysics, Research Center Borstel, Borstel, Germany Centre for Strctural Systems Biology, Hamburg, Germany
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51
2.40 pm |
How do plants sense temperature?
Nanostructure characterization of biological hydrogels formed by the prion-like domain EARLY FLOWERING 3 using SAXS
Mark Tully BM29 BioSAXS, ESRF, Grenoble, France
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52
2.55 pm |
The complex choreography of gelsolin, a master regulator of cytoskeleton
Loic Girois MolBD3, istituto di biofisica IBF Milano, Milano, Italy
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53
3.10 pm |
Circular dichroism spectroscopic study on the metal ion selectivity of the AfArsR model peptide
Bela Gyurcsik Department of Molecular and Analytical Chemistry, University of Szeged, Hungary, Szeged, Hungary
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54
3.25 pm |
Biophysical characterisation of oligomeric states of pyroglutamate-modified alpha-synuclein
Alexandra Bluhm University of Leipzig, Leipzig, Germany
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55
3.40 pm |
Fluidic Sciences
James Wilkinson Fluidic Sciences, Royston, United Kingdom
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56
3.50 pm |
Explore the unknown, Choose SPR and Biacore™ systems
Claire Shepherd Global Product Manager – Biacore Consumables - Cytiva, France
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57
4.30 pm |
Pathogenicity of enterobacterial strains isolated from urinary tract infections in BENIN and searching for plant-derived bioactive molecules (Zoom conference)
Funke Faizatou Assouma faculty of science and technology, laboratory of biology and molecular typing in microbiology, University of Abomey Calavi, Seme Podji, Benin
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58
4.45 pm |
Subsite binding in the yin-and-yang Bacteroides thetaiotaomicron sialidase at 1.5 Å resolution
Julie Bouckaert Unité de Glycobiologie Structurale et Fonctionnelle - UGSF, UMR 8576 CNRS & Lille University, Villeneuve D'ascq, France
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59
5.00 pm |
Conductive protein-based biomaterials: from the design to the application
Paolo Blesio Biomolecular Nanotechnology group, Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research And Technology Alliance (brta), Paseo De Miramon 194, Donostia/san Sebastian. 20014, Spain
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60
5.15 pm |
Insights into the structure-activity relationship of SMAD4 variants associated with Myhre syndrome
Carles Torner Institute for Research in Biomedicine, Barcelona, Spain
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61
5.30 pm |
Unlocking Molecular Truths with SEC-MALS for Proteins, RNA, and Nanobodies
Philippe Boniteau Application Scientist at Waters | Wyatt Technology, United States
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62
5.40 pm |
Molecular biophysics meets parasitology: how to select biomarkers to test schistosomiasis infections
Adriana Erica Miele UMR 5280 Institut des Sciences Analytiques, Université Claude Bernard Lyon 1, Villeurbanne, France
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3rd Poster session |
6.05 pm-7.00 pm
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Conference dinner |
7.45 pm-11.00 pm
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Friday, June 13, 2025
Welcome coffee |
08.30 am-09.15 am
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Single molecule/single particle biophysics |
09.15 am-12.45 pm
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Chairs: Patrick England, Institut Pasteur, France - Wouter Roos, Rijksuniversiteit Groningen, The Netherlands |
63
09.15 am |
The complex task of simplifying biology
Petra Schwille Director, Cellular and Molecular Biophysics Max Planck Institute of Biochemistry, Martinsried, Germany
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64
09.55 am |
Exploring single molecule unbinding near to equilibrium by acoustic force spectroscopy
Claire Valotteau DyNaMo, Inserm, Aix-Marseille Université, Marseille, France DyNaMo, CNRS, Marseille, France
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65
10.10 am |
Manipulation of large protein complexes with DNA forceps: Deciphering binding mechanisms and testing molecular heterogeneity
Charlie Gosse Institut de Biologie de l'Ecole Normale Supérieure, CNRS, Paris, France
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66
10.25 am |
Tracking and tracing complex DNA structures critical to human health
Alice Pyne University of Sheffield, Sheffield, United Kingdom
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67
10.50 am |
Modifying Norovirus capsid assembly through N-terminal mutations.
Jennifer Rothe Center for Structural Systems Biology, Hamburg, Germany University of Groningen, Groningen, The Netherlands
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68
11.35 am |
Single-molecule optical tweezers applied to transmembrane proteins
Katarzyna (kasia) Tych Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, The Netherlands
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69
12.00 pm |
Single-molecule and multiscale fluorescence imaging to investigate PD-L1 dynamics and its association with lipid raft in Non-Small Cell Lung Cancer cells
Simone Civita Department of Surgical, Medical and Molecular Pathology, and Critical Care Medicine, University of Pisa, Pisa, Italy
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70
12.15 pm |
Molecular mechanisms of Hepatitis B virus capsid protein interactions with the viral genome
Yanping Gong Moleculaire Biofysica, Zernike Instituut, Rijksuniversiteit Groningen, Groningen, The Netherlands
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71
12.30 pm |
Disorder, assembly and function: the molecular behavior of disordered translation factors across multifaceted self-association landscape
Mikayel Aznauryan ARNA U1212, IECB, INSERM - Universite de Bordeaux, Pessac, France
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Concluding remarks/end of conference |
12.45 pm-1.00 pm
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